bioimaging sciences | faculty | de Graaf Robin A. de Graaf, Ph.D. Assistant Professor Yale University, School of Medicine Department of Diagnostic Radiology System Manager Human 4 Tesla NMR Magnet Yale Magnetic Resonance Center 126 MRC, 330 Cedar Street New Haven, Connecticut 06520-8043, United States Phone: (203) 785-6203 Fax: (203) 785-6643 robin.degraaf@yale.edu

The main focus of my research is to study cerebral energy metabolism and its relationship to functional activation in human and animal brain. NMR spectroscopy (proton, (inverse) carbon-13 and phosphorus-31) is the most important tool to study metabolic processes and fluxes non-invasively in vivo. Besides studying brain energy metabolism, a significant part of the research is reserved for technological and methodological improvements to the technique of NMR spectroscopy. These include methods for better water suppression, spatial localization, spectral editing, quantification and shimming.

Selected references

Books

R. A. de Graaf, "In vivo NMR spectroscopy. Principles and techniques", John Wiley, Chichester (1998)

Articles

R. A de Graaf, J.W. Pan, F.Telang, J-H. Lee, P. Brown, E. J. Novotny, H. P. Hetherington, D. L. Rothman, Differentiation of glucose transport in human brain gray and white matter, J. Cereb. Blood. Flow Metab. 21, 483-492 (2001)

R. A. de Graaf, R. M. Dijkhuizen, K. P. J. Braun, G. J. Biessels, K. Nicolay, Glucose detection by homonuclear spectral editing, Magn. Reson. Med. 43, 621-626 (2000)

R. A. de Graaf, A. van Kranenburg, K. Nicolay, In vivo ³¹P NMR diffusion measurements of phosphocreatine and ATP in rat skeletal muscle, Biophys. J. 78, 1657-1664 (2000)

R. A. de Graaf, K. Nicolay, Adiabatic water suppression using frequency selective excitation, Magn. Reson. Med. 40, 690-696 (1998)

R. A. de Graaf, K. Nicolay, M. Garwood, Single shot, B1 insensitive slice selection with a gradient-modulated adiabatic pulse, BISS-8, Magn. Reson. Med. 35, 652-657 (1996)