Fahmeed Hyder, Ph.D.

Associate Professor of Diagnostic Radiology and Biomedical Engineering

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, N143, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: fahmeed.hyder@yale.edu
Telephone: (203) 785-6205
Fax: (203) 785-6643

Education

PhD, Yale University, Physical Chemistry / Biophysics and Biochemistry, 1995.

BA, Wabash College, Physical Chemistry, 1990.

Please click here for Curriculum Vitae

Research Interests

Dr. Hyder is the Director of the Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR) at Yale University. His interests span several areas in brain imaging: quantitative neuroimaging, neurometabolic and neurovascular coupling, oxygen consumption and transport, and translation of smart contrast agents. His laboratory combines magnetic resonance, electrophysiology, and optical imaging techniques to explore large scale mechanisms of brain function that underlies cortical sensory activities.

Specific topics of interest in his laboratory:

• High spatiotemporal resolution fMRI at ultra-high fields: Sensory columns at extremely high resolution.
• Electrophysiological basis of BOLD signal: Excitatory and inhibitory neural events underlying the BOLD response.
• Rheological basis of BOLD signal: Contributions of blood plasma and erythrocytes on the BOLD response.
• Energetics of neuronal populations by fMRI: Subcortical mechanisms underlying cortical activations for unisensory and multisensory stimuli.
• Translation of smart contrast agents for tumor characterization by MR: Synthesize and translate agents for improved biosensing of pH and temperature by MR.

Selected Publications

1. Shulman RG, Rothman DL, Hyder F (2007) A BOLD search for baseline. NeuroImage. 36:277-281
2. Maandag NJG, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F (2007) Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci USA. 104:20546-20551
3. Riera JJ, Schousboe A, Waagepetersen HS, Howarth C, Hyder F (2008) The micro-architecture of the cerebral cortex: Functional neuroimaging models and metabolism. Neuroimage. 40:1436-1459.
4. Sanganahalli BG, Herman P, Hyder F (2008) Frequency-dependent tactile responses in rat brain by fMRI. NMR Biomed. 21:410-416.
5. Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H (2008) Negative BOLD with large increases in neuronal activity. Cereb Cortex. 18:1814-1827.
6. Hyder F (2008) Dynamic imaging of brain function. Methods Mol Med. 489:3-21.
7. Sanganahalli BG, Bailey CJ, Herman P, Hyder F (2008) Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents. Methods Mol Med. 489:213-242.
8. Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H (2008) Remote effects of focal hippocampal seizures on the rat neocortex. J Neurosci. 28:9066-9081.
9. Herman P, Sanganahalli BG, Hyder F (2008) Multi-modal measurements of blood plasma and red blood cell volumes during functional brain activation. J Cereb Blood Flow Metab. (in press)
10. Coman D, Trübel HK, Rycyna RE, Hyder F (2008) Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. NMR Biomed. (in press)

Recent Books      

Hyder, F (2009). Dynamic Brain Imaging: Multi-Modal Methods and In Vivo Applications. Humana Press Inc (Totowa, New Jersey, USA).

For a further list of Hyder’s publications, please see PubMed.

Current and Former Trainees 

• Wakil Ahmed (summer intern), 2004, MATLAB and SIMULINK coding for Roverbot. Presently, Undergraduate Student, Johns Hopkins University, Baltimore, MD, USA.
• Rabi Alam (summer intern), 2006, Open GL and MATLAB coding for analyzing diffusion tensor imaging data. Presently, Undergraduate Student, Bard College of Simon's Rock, Great Barrington, MA, USA.
• Christopher J. Bailey (1 publication), 2006-2008, PhD Student (expected PhD 07/2009), Aarhus University, Aarhus, Denmark. Presently, Research Associate, Aarhus PET Centre, CFIN, Aarhus, Denmark.
• Halima Chahboune (2 publications), 2003-2007, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA
• Daniel Coman (2 publications),  2004-2007, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA.
• Dario J. Englot (1 publication), 2006-2008, MD-PhD Student (expected MD-PhD 05/2009), School of Medicine, Yale University, New Haven, CT, USA. Presently, MD-PhD Student, School of Medicine, Yale University, New Haven, CT, USA.
• Alysha Fahmi (summer intern), 2007, auditory stimulus delivery system. Presently, Undergraduate Student, University of California at Berkeley, Berkley, CA, USA
• Jacqueline A. Farber (1 publication), 2001-2003, Undergraduate Student, Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Presently, MD-PhD Student, School of Medicine, University of California, San Diego, CA, USA.
• Peter Herman (12 publications), 2002-2005, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA.
• Atif Khandaker (summer intern), 2006, visual/auditory stimulus delivery system. Presently, Video Editor, Darrell Crow Studios, Bellingham, MA, USA. Presently, Undergraduate Student, Worcester Polytechnic Institute, Worcester, MA, USA.
• Nabil Khandker (summer intern), 2006, convection enhanced delivery of drugs into brain.  Presently , MD Student, School of Medicine, Ross University, Roseau, Commonwealth of Dominica, West Indies.
• Manjula Khubchandani (1 publication), 2001-2006, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Scientist, Department of NMR, All India Institute of Medical Sciences, New Delhi, India. Presently, Assistant Professor, Department of Chemistry, Government Model Science College, Jabalpur, India.
• Ikuhiro Kida (17 publications), 1998-2001, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. 2001-2004, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Assistant Professor, School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
• Paul K. Maciejewski (4 publications), 2000-2003, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Assistant Professor, Psychiatry, Yale University, New Haven, CT, USA.
• Natasja J. Maandag (1 publication),  2000-2002, MD Student (received MD 01/2004), University Medical Centre, Nijmegen, The Netherlands. Presently, Resident in Training, Anaesthesiology, University Medical Centre, Nijmegen, The Netherlands.
• Hrachya Nersesyan (2 publications), 2001-2003, Post-Doctoral Associate, Neurology, Yale University, New Haven, CT, USA. Presently, Assistant, Professor, Neurology, University of Illinois, College of Medicine at Peoria, Peoria, IL, USA.
• Remco Renken (3 publications), 1998-2001, PhD Student (received PhD 07/2003), Neurobiophysics, University of Groningen, Groningen, The Netherlands. Presently, Assistant Professor, Medical Physiology, University Medical Center Groningen, The Netherlands.
• Laura S. Sacolick (1 publication),  2004-2006, PhD Student (received PhD 12/2007), Biomedical Engineering, Yale University, New Haven, CT, USA. Presently, Pulse Programmer, General Electric, Munich, Germany.
• Basavaraju G. Sanganahalli (7 publications), 2003-2007, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA.
• James R. Schafer (3 publications), 2002-2005, MD-PhD Student (received MD-PhD 05/2006), School of Medicine, Yale University, New Haven, CT, USA. Presently, Resident in Training, Radiology, University of Michigan, Ann Arbor, MI, USA.
• Mohammad Siddeek (2 publications), 1993-1996, Undergraduate Student, Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. 1996-1997, Graduate Student, Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
• Alyssa Siefert (summer intern), 2006, visual stimulus delivery system. Presently, Undergraduate Student, Carnegie Mellon University, Pittsburgh, PA, USA.
• Arien J. Smith (4 publications), 2001-2002, MD Student (received MD 05/2004), School of Medicine, Yale University, New Haven, CT, USA. Presently, Resident in Training, Neurosurgery, Mount Sinai Hospital, New York, NY, USA.
• Hubert K. Trübel (8 publications), 2001-2003, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Lecturer, Witten/Herdecke University, Wuppertal, Germany. Presently, Head, Cardiovascular Physiology, Bayer Health Care AG, Wuppertal, Germany.
• Fuqiang Xu (7 publications), 1999-2002, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. 2002-2006, Associate Research Scientist, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Assistant Professor, Wuhan Institute of Physics and Mathematics, Wuhan, China.
• Xiaojin Yang (3 publications), 1992-1998, PhD Student, Chemistry, Yale University, New Haven, CT, USA. 1998-1999, Post-Doctoral Associate, Diagnostic Radiology, Yale University, New Haven, CT, USA. Presently, Biotechnology Analyst, Symmetry Capital, San Francisco, CA.