bioimaging sciences | faculty | Hyder Fahmeed Hyder Associate Professor of Diagnostic Radiology and Biomedical Engineering Ph.D. 1994 Yale University Yale University, School of Medicine Department of Diagnostic Radiology fahmeed.hyder@yale.edu Biographical Sketch

My research interests revolve around the development of in vivo NMR methods for measurements of cerebral metabolic rate of oxygen consumption (CMRO2) blood flow (CBF) and volume (CBV). Measurements of CBF, CBV, andCMRO2 at various levels of activity are combined for understandings of blood oxygenation level dependent (BOLD) functional MRI (fMRI) image contrast and mechanisms of cerebral oxygen delivery.

For these objectives,
-BOLD fMRI models of sensory activation of sensorimotor cortex and olfactory bulb in the rat have been developed;
-high spatial resolution absolute CMRO2 mapping has been achieved witha combination of an echo-planar based acquisition implemented with {13C}-1H J editing spectroscopy;
-by calibration of the BOLD fMRI image contrast at a specific static magnetic field strength, even higher spatial resolution relative CMRO2 mapping has been been achieved with multi-modal MRI methods, and
-theoretical models of cerebral oxygen delivery have been developed which enable characterization of the microscopic event(s) and/or episode(s) that may be involved in regulating tissue oxygenation.

Most of the work has been done on a 7 Tesla horizontal wide bore spectrometer at the Yale Magnetic Resonance Research Center

Recent Publications

Hyder F. Rothman DL. Shulman RG. Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proceedings of the National Academy of Sciences of the United States of America. 99(16):10771-6, 2002 Aug 6.

Shulman RG. Hyder F. Rothman DL. Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proceedings of the National Academy of Sciences of the United States of America. 98(11):6417-22, 2001 May 22.

Hyder F. Kida I. Behar KL. Kennan RP. Maciejewski PK. Rothman DL. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR in Biomedicine. 14(7-8):413-31, 2001 Nov-Dec.