bioimaging centers | magnetic resonance research center | faculty | Behar Kevin Behar, Ph.D. Research Scientist Yale University, School of Medicine Department of Diagnostic Radiology Yale Magnetic Resonance Center N151 CAB, 300 Cedar Street New Haven, Connecticut 06520-8043, United States Phone: (203) 737-4121 Fax: (203) 785-6643 kevin.behar@yale.edu Biographical Sketch

Selected Publications

Behar KL, den Hollander JA, Stromski ME, Ogino T, Shulman RG, Petroff OAC, Prichard JW (1983). High resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc. Natl. Acad. Sci. (USA). 80: 4945-4948.

Fitzpatrick SM, Hetherington HP, Behar KL, Shulman RG (1990). The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy. J. Cereb. Blood Flow Metab. 10: 170-179.

Mason GF, Rothman DL, Behar KL, Shulman RG (1992). NMR determination of the TCA cycle rate and a-ketoglutarate/glutamate exchange rate in rat brain. J Cereb. Blood Flow Metab 12: 434-447.

Rothman DL, Petroff OAC, Behar KL, Mattson RH (1993) Localized 1H NMR measurements of GABA in human brain in vivo. Proc. Natl. Acad. Sci. USA, 90: 5662-5666.

Petroff OAC, Rothman DL, Behar KL, Mattson RH (1995) Initial observations on the effect of vigabatrin on in vivo 1H spectroscopic measurements of GABA, glutamate, and glutamine in human brain. Epilepsia, 36: 457-464.

Manor D, Rothman DL, Mason GF, Hyder F, Petroff OAC, Behar KL (1996) The rate of turnover of cortical GABA from [1-13C] glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (?-vinyl GABA). Neurochem. Res., 21:1031-1041.

Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc. Natl. Acad. Sci. 95:316-321.

Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OAC, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH (1999) Preliminary evidence of reduced cortical GABA levels in localized 1H-MR spectra of alcohol dependent and hepatic encephalopathy patients. Am. J. Psychiat., 156:952-954.

Novotny EJ, Ariyan C, Mason GF, O'Reilly J, Haddad GG, Behar KL (2001) Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Res., 888:193-202.

Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JEM, Behar KL, Rothman DL, Shulman RG (2001) In vivo 13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis, and TCA cycle flux during [2-13C]glucose infusion in rat brain. J. Neurochem., 76:975-989.

Patel AB, Rothman DL, Cline GW, Behar KL (2001) Glutamine is a major precursor for GABA synthesis in rat cortex in vivo following acute GABA-transaminase inhibition. Brain Res., 919(2):207-20.

Lebon V, Petersen KF, Cline GW, Shen J, Mason GF, Dufour S, Behar KL, Shulman GI, Rothman DL (2001) Measurement of total neuronal/astroglial glutamate-glutamine trafficking and astroglial TCA cycle flux in human cerebral cortex using 13C NMR spectroscopy during the infusion of [2-13C]acetate, J. Neurosci.,22(5):1523-1531.

Mason GF, Martin DL, Martin SB, Manor D, Sibson NR, Patel AB, Rothman DL, Behar KL (2001) Decease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein, Brain Res., 914(1-2):81-91.