The Yale Magnetic Resonance Research Center (MRRC) was founded in 1986 as a result of the recognition that NMR applications, as pioneered by Yale scientists, have enormous potential in biomedical research. The MRRC is now an interdepartmental and interdisciplinary research laboratory that provides state-of-the-art MR equipment, infrastructure and expertise for the development and application of MRI and MRS methodology in biomedical research. Research is focused on the study of intact biological systems by developing methods for obtaining structural, functional, physiological and biochemical information by MRI, MRS and other techniques. Applications include fMRI for neurosurgery and neuroscience, brain, muscle and liver energy metabolism, diabetes, adult and juvenile epilepsy and psychiatric disorders.