Dorit Granot, PhD

Postdoctoral Associate
Mentor: Erik Shapiro

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, NL147, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: dorit.granot@yale.edu
Telephone: (203) 785-5648
Fax: (203) 785-6643

Education

2007 PhD in Biology, Weizmann Institute of Science, Rehovot, Israel.

2000 M.Sc in Biochemistry, Hebrew University of Jerusalem, Jerusalem, Israel.

1997 B.Sc in Biology, Hebrew University of Jerusalem, Jerusalem, Israel.

Please click here for Curriculum Vitae

Research Interests

Specific types of cells are recruited towards distantly located targets, both under normal conditions as well as in pathologies. Hence, fibroblasts and immune cells that migrate to epithelial tumors promote tumor progression and metastasis formation. Similarly, neural progenitor cells constantly migrate from the neural stem cell niche (the SVZ) via the rostral migratory stream to the olfactory bulb, where they differentiate into mature neurons. Upon stroke, lack of blood supply to the infarct region results in massive cell death. Consequently, cytokines and chemokines are released to increase neuron stem cell proliferation and migration of progenitor cells to the infarct. How do these cells migrate and establish new connections? Can we manipulate these biological pathways so as to provide better recovery? MRI for cellular and molecular imaging in combination with conventional confocal microscopy is used to address these questions in a rat model.

Selected Publications

1. In vivo imaging of fibroblasts recruitment into ovarian carcinoma tumors. Granot D, Addadi Y, Kalchenko V, Kunz-Schughart L. A, and Neeman M. Cancer Res. 2007 Oct 1;67(19):9180-9.
2. Labeling fibroblasts with biotin-BSA-GdDTPA-FAM for tracking of tumor-associated stroma by fluorescence and MR imaging. Granot D, Kunz-Schughart L.A, Neeman M. Magn Reson Med. 2005 Oct;54(4):789-97.
3. Longitudinal MRI tracking of the angiogenic response to hind limb ischemic injury in the mouse. Ziv K, Nevo N, Dafni H, Israely T, Granot D, Brenner O, Neeman M. Magn Reson Med. 2004 Feb;51(2):304-11.
4. Vascular remodeling and angiogenesis in ectopic ovarian transplants: a crucial role of pericytes and vascular smooth muscle cells in maintenance of ovarian grafts. Israely T, Dafni H, Granot D, Nevo N, Tsafriri A, Neeman M. Biol Reprod. 2003 Jun;68(6):2055-64. Epub 2003 Jan 22.
5. Small is mighty: EmrE, a multidrug transporter as an experimental paradigm. Schuldiner S, Granot D, Mordoch SS, Ninio S, Rotem D, Soskin M, Tate CG, Yerushalmi H. News Physiol Sci. 2001 Jun;16:130-4. Review.
6. Precious Things Come in Little Packages. Schuldiner S, Granot D, Mordoch SS, Ninio S, Rotem D, Soskin M, Yerushalmi H. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):155-62. Review.
7. Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter from Escherichia coli, Reveals a Hydrophobic Pathway for Solutes. Steiner Mordoch, S., Granot, D., Lebendiker, M., and Schuldiner, S. (1999) J. Biol. Chem. 274, p. 1480-86.