Giampaolo Tomasi, PhD

Postdoctoral Associate
Mentor: Richard E. Carson

Contact

Address:
Yale University, School of Medicine
901 Howard Avenue
New Haven, Connecticut 06520-8048
United States

Email: giampaolo.tomasi@yale.edu
Telephone: (203) 785-6628
Fax: (203) 785-3107

Education

Dec 2004 - Dec 2007: PhD program in Bioengineering at the University of Padova, Italy.
PhD Thesis: ”Bayesian and population approaches for pixel-wise quantification in positron emission tomography: ridge regression and global-two-stage.”
Thesis advisors: Prof. Claudio Corbelli, Prof. Alessandra Bertoldo.

Sep 1999 - Oct 2004: Graduation in Electronics Engineering (with specialization in Bioengineering): grade 110/110 cum laude.
Graduation Thesis: ”Methods of prediction of hypo- and hyperglycaemias from continuous glucose monitoring data”
Thesis advisors: Prof. Claudio Corbelli, Prof.Giovanni Sparacino.

Please click here for Curriculum Vitae

Research Interests

My research interests are in the field of Positron Emission Tomography (PET), with particular emphasis on kinetic modelling and, more specifically, on Bayesian methods applied to parametric images. I have also been extensively studying the issue of the in-vivo estimation, in non-human primates, of the local receptor concentration Bmax and tracer-receptor dissociation constant Kdapp from Scatchard studies and Bolus+Infusion protocols. Another topic on which I have been focusing is the characterization of the effect of a given drug from occupancy studies by estimating the IC50 of the compound in non-human primates, as a preliminary step towards employment of the drug in humans.

Selected Publications

Papers

1. Tomasi.G., Edison.P., Bertoldo.A., Roncaroli.F., Singh.P., Gerhard.A., Cobelli.C., Brooks.D.J., Turkheimer.FE. ”Novel reference region modelling reveals increased microglial and reduced vasculature binding of [11C]-(R)-PK11195 in Alzheimer’s disease patients”, J Nucl Med. 2008 Aug;49(8):1249-56.
2. Tomasi.G., Bertoldo.A., Cobelli.C. ”PET parametric imaging improved by Global-Two-Stage”, submitted to Annals of Biomedical Engineering, positive second review
3. Tomasi..G., Bertoldo.A., Shrinivas Bishu.S., Unterman.A., Smith.C.B., Schmidt. K.C. “Voxel-based estimation of kinetic model parameters of the L[1-11C]leucine PET method for determination of regional rates of cerebral protein synthesis: Validation and comparison with region-of-interest based methods” submitted to Journal of Nuclear Medicine, November 2008.

Short Papers & Abstracts

1. Tomasi.G., Bertoldo.A., Cobelli.C. ”Parametric imaging of acetylcolinesterase activity with PET: evaluation of different methods“ Proceedings of IFAC MCBMS 2006, Reims.
2. Tomasi.G., Bertoldo.A., Cobelli.C. ”Parametric imaging of [11C]MP4A: comparison of different methods on simulated data” Neuroimage,VOL.31b,2006.
3. Tomasi.G., Bertoldo.A., Edison.P., Roncaroli.F., Pavese.N., Gerhard.A., Tai.Y., Cobelli.C., Brooks.D.J., Hammers.A., Turkheimer.FE. ”Increased binding potential of [11C]PK11195 in Alzheimer’s disease by new SRTM accounting for blood volume” Proceedings of the 8th International Conference on Quantification of  Brain Function with PET, Osaka, Japan, 20-24 May 2007.
4. Tomasi.G., Bertoldo.A., Bovo.V., Cobelli.C. ”Global two stages approach for [11C]DASB parametric imaging: evaluation on simulated data” Proceedings of the 8th International Conference on Quantification of  Brain Function with PET, Osaka, Japan, 20-24 May 2007.
5. Turkheimer.FE ,Tomasi.G., Edison.P., Bertoldo.A., Roncaroli.F., Singh.P., Cobelli.C., Gerhard.A., ,Brooks.D.J. ”Increased binding potential of [11C]PK11195 in Alzheimer’s disease by new SRTM accounting for blood volume” Proceedings of the Second International Conference of the European Society for Molecular Imaging, Naples, Italy,14-15 June 2007.
6. Tomasi.G., Bertoldo.A., Schmidt. K.C., Turkheimer.FE, Smith.C.B., Cobelli.C. “Residual-based comparison of different weighting schemes for pixel-wise kinetic analysis at the pixel level in PET”. Proceedings of Neuroreceptor Mapping 2008, The Seventh International Symposium on Functional Neuroreceptor Mapping of Living Brain, published in NeuroImage,Volume 41, Supplement 2, 2008, Page T84.
7. Tomasi.G., Nabulsi.N., Weinzimmer.D., Sandiego C., Gallezot.J.D., Wang.E., McLean.S., Huang H., Ding.Y.S. and Carson.R.E. “In vivo Scatchard analysis of bolus/infusion 5-HT1B studies with [11C]P943: Comparison between SRTM and equilibrium methods” Proceedings of Neuroreceptor Mapping 2008, The Seventh International Symposium on Functional Neuroreceptor Mapping of Living Brain, published in NeuroImage, Volume 41, Supplement 2, 2008, Page T84.